Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Sui Zhang, Xiaobing Liu, Tasneem Bawa-Khalfe, Long Sheng Lu, Yi Lisa Lyu, Leroy-Fong Liu, Edward T H Yeh

研究成果: 雜誌貢獻文章同行評審

1124 引文 斯高帕斯(Scopus)

摘要

Doxorubicin is believed to cause dose-dependent cardiotoxicity through redox cycling and the generation of reactive oxygen species (ROS). Here we show that cardiomyocyte-specific deletion of Top2b (encoding topoisomerase-IIβ) protects cardiomyocytes from doxorubicin-induced DNA double-strand breaks and transcriptome changes that are responsible for defective mitochondrial biogenesis and ROS formation. Furthermore, cardiomyocyte-specific deletion of Top2b protects mice from the development of doxorubicin-induced progressive heart failure, suggesting that doxorubicin-induced cardiotoxicity is mediated by topoisomerase-IIβ in cardiomyocytes.

原文英語
頁(從 - 到)1639-1642
頁數4
期刊Nature Medicine
18
發行號11
DOIs
出版狀態已發佈 - 11月 2012
對外發佈

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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