Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus

Su Fang Lin, Dan R. Robinson, Joe Oh, Jae U. Jung, Paul A. Luciw, Hsing Jien Kung

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Rhesus monkey rhadinovirus (RRV) is a γ2-herpesvirus identified from the peripheral blood mononuclear cells of rhesus macaques (Macaca mulatta). Serologic studies suggested that the infections of RRV are prevalent among rhesus monkeys. RRV can be efficiently propagated and grows to a high titer in cultured rhesus monkey fibroblasts, thus providing a valuable model to study the rhadinovirus replication. By comparative genomic studies, here we describe the identification of two potential transcriptional factors encoded by RRV, designated as R-Rta and R-bZIP. Initial functional characterization of these products suggested that R-Rta is a potent transcriptional activator and R-bZIP forms homodimers in vivo. Viral homologues of R-Rta and R-bZIP, previously identified from other rhadinoviruses, have been implicated in serving as molecular switches in lytic replication.
原文英語
頁(從 - 到)181-188
頁數8
期刊Virology
298
發行號2
DOIs
出版狀態已發佈 - 一月 1 2002
對外發佈

ASJC Scopus subject areas

  • 病毒學

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