Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases

Shih Hsin Hsiao, Chi Li Chung, Yu Ting Chou, Hsin Lun Lee, Sey En Lin, H. Eugene Liu

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age
原文英語
頁(從 - 到)319-323
頁數5
期刊Lung Cancer
82
發行號2
DOIs
出版狀態已發佈 - 十一月 2013

指紋

Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Logistic Models
Medical Records
Regression Analysis
Quality of Life
Survival
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

引用此文

Identification of subgroup patients with stage IIIB/IV non-small cell lung cancer at higher risk for brain metastases. / Hsiao, Shih Hsin; Chung, Chi Li; Chou, Yu Ting; Lee, Hsin Lun; Lin, Sey En; Liu, H. Eugene.

於: Lung Cancer, 卷 82, 編號 2, 11.2013, p. 319-323.

研究成果: 雜誌貢獻文章

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abstract = "Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36{\%}) experienced BM during their disease course. On MLR analysis, female gender, age",
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AU - Hsiao, Shih Hsin

AU - Chung, Chi Li

AU - Chou, Yu Ting

AU - Lee, Hsin Lun

AU - Lin, Sey En

AU - Liu, H. Eugene

PY - 2013/11

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N2 - Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age

AB - Purpose: Brain metastases (BM), a common occurrence in non-small cell lung cancer (NSCLC), usually lead to a poor prognosis. Recently, the selection of treatment modalities for BM has modestly improved patient survival and quality of life. Treatment choice is largely based on the number of BM, the presence of BM-related symptoms, and performance status. Therefore, early BM detection is crucial. In this study, we aimed to elucidate the factors associated with BM and identify subgroups of patients at higher risk for BM. Methods and patients: The medical records of 596 consecutive patients with stage I-IV NSCLC were reviewed between January 2006 and November 2011. A multivariate logistic regression (MLR) model was used to identify factors associated with BM. Results: Among 482 eligible stage IIIB/IV NSCLC patients, 173 (36%) experienced BM during their disease course. On MLR analysis, female gender, age

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