Identification of hair shaft progenitors that create a niche for hair pigmentation

Chung Ping Liao, Reid C. Booker, Sean J. Morrison, Lu Q. Le

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Hair differentiates from follicle stem cells through progenitor cells in the matrix. In contrast to stem cells in the bulge, the identities of the progenitors and the mechanisms by which they regulate hair shaft components are poorly understood. Hair is also pigmented by melanocytes in the follicle. However, the niche that regulates follicular melanocytes is not well characterized. Here, we report the identification of hair shaft progenitors in the matrix that are differentiated from follicular epithelial cells expressing transcription factor KROX20. Depletion of Krox20 lineage cells results in arrest of hair growth, confirming the critical role of KROX20+ cells as antecedents of structural cells found in hair. Expression of stem cell factor (SCF) by these cells is necessary for the maintenance of differentiated melanocytes and for hair pigmentation. Our findings reveal the identities of hair matrix progenitors that regulate hair growth and pigmentation, partly by creating an SCF-dependent niche for follicular melanocytes.
原文英語
頁(從 - 到)744-756
頁數13
期刊Genes and Development
31
發行號8
DOIs
出版狀態已發佈 - 四月 15 2017
對外發佈Yes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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