Identification of FKBP11 as a biomarker for hepatocellular carcinoma

I. Yin Lin, Chia Hung Yen, Yi Jen Liao, Sey-En Lin, Hon Ping Ma, Yu Jiun Chan, Yi Ming A Chen

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16 引文 斯高帕斯(Scopus)


Background: Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11. Patients and Methods: FKBP11 expression levels were analyzed in 123 paired tumor and tumor-Adjacent non-tumorous (TA) tissue samples from patients with HCC and in 29 benign liver samples from patients with hemangioma using quantitative real-time polymerase-chain-reaction. Results: FKBP11 was expressed at a higher level in tumor tissues compared to TA tissues (p
頁(從 - 到)2763-2770
期刊Anticancer Research
出版狀態已發佈 - 6月 2013

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科


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