Identification of calcineurin as a key signal in the extinction of fear memory

Chih Hung Lin, Shiu Hwa Yeh, Tzeng Horng Leu, Wen Chang Chang, Shan Tair Wang, Po Wu Gean

研究成果: 雜誌貢獻文章

136 引文 斯高帕斯(Scopus)

摘要

Memory extinction refers to a gradual decrease of the previously acquired response when exposed to conditional stimulus without pairing with unconditional stimulus. Here we show for the first time that fear training-induced phosphorylation of specific substrates in the rat amygdala is reduced after extinction trials and is accompanied by an increase in the protein level and enzymatic activity of calcineurin. In parallel, calcineurin inhibitors prevented extinction-induced protein dephosphorylation as well as extinction of fear memory. Thus, extinction training increased phosphatase activity likely via an expression of calcineurin. Calcineurin then created a negative-feedback loop and directly or indirectly dephosphorylated specific substrates, which, in their phosphorylated state, were required for memory consolidation. Accordingly, in our experimental condition, extinction could be ascribed at least in part to a weakening of the original signaling.

原文英語
頁(從 - 到)1574-1579
頁數6
期刊Journal of Neuroscience
23
發行號5
出版狀態已發佈 - 三月 1 2003
對外發佈Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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  • 引用此

    Lin, C. H., Yeh, S. H., Leu, T. H., Chang, W. C., Wang, S. T., & Gean, P. W. (2003). Identification of calcineurin as a key signal in the extinction of fear memory. Journal of Neuroscience, 23(5), 1574-1579.