Identification of angiotensin I-converting enzyme inhibitory peptides derived from the peptic digest of soybean protein

Jiun-Rong Chen, Takashi Okada, Koji Muramoto, Kunio Suetsuna, Suh-Ching Yang

研究成果: 雜誌貢獻文章

59 引文 斯高帕斯(Scopus)

摘要

Peptidic fractions which inhibit angiotensin I-converting enzyme (ACE) were separated from peptic digests of soybean by ion exchange chromatography and gel filtration. Further separation of the peptidic fractions by ODS HPLC afforded active peptides, the amino acid sequences of which were identified by Edman's procedure as: Ile-Ala (inhibitory against ACE with an IC50 of 153 μM), Tyr-Leu-Ala-Gly-Asn-Gln (14 μM), Phe-Phe-Leu (37 μM), Ile-Tyr-Leu-Leu (42 μM), and Val-Met-Asp-Lys-Pro-Gln-Gly (39 μM). The antihypertensive activity of the soybean peptides was also investigated. Peptide fractions (2.0 g/kg body weight, oral administration) markedly lowered the blood pressure of spontaneously hypertensive rats (SHRs).
原文英語
頁(從 - 到)543-554
頁數12
期刊Journal of Food Biochemistry
26
發行號6
出版狀態已發佈 - 十二月 2002

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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