Ibuprofen augments pro-inflammatory cytokine release in a mouse model of Vibrio vulnificus infection

Yuarn Jang Lee, Yin Ching Chuang

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

We evaluated the effects of ibuprofen on cytokine production and mortality in a mouse model of septic shock induced by Vibrio vulnificus, strain Chi Mei Vv05191. Ibuprofen (50 mg/kg) or saline (control) was given to female BALB/cByJ mice for three consecutive days before exposure to the pathogen. For cytokine production, serum and peritoneal fluid were assayed for IL-1β, IL-6, TNF-α, and MIP-2 by ELISA at 3, 6, and 9 hr after intraperitoneal infection of the organism. At 6 hr after infection, serum and peritoneal fluid levels of IL-6, TNF-α, and MIP-2 were significantly higher in the ibuprofen group. For mortality determination, 73 mice (37 ibuprofen, 36 control) were injected intramuscularly with V. vulnificus. Kaplan-Meier survival curves were analyzed. Survival was significantly decreased by ibuprofen only for the lowestinoculum(25 CFU)of V. vulnificus. Administration of ibuprofen before infectionmay augment the pathogenesis of V. vulnificus by stimulating cytokine production.

原文英語
頁(從 - 到)542-550
頁數9
期刊Microbiology and Immunology
54
發行號9
DOIs
出版狀態已發佈 - 一月 1 2010

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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