Hypolipidemic effects of different angiocarp parts of Alpinia zerumbet

Chao Ming Chuang, Hui Er Wang, Chiung Chi Peng, Kuan Chou Chen, Robert Y. Peng

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


Context: In utilization of Alpinia zerumbet (Pers.) Burtt and Smith (Zingiberaceae) (AZ), usually the angiocarps are discarded without further use. Objective: We speculate whether the angiocarps could show hypolipidemic effect. Methods and methods: Several diets were prepared: Alpinia seed powder (ASP); Alpinia seed powder/husk (ASH): 40/60; and Alpinia seed essential oil (ASO): 0.010.10%. Sprague-Dawley rats divided into 11 groups were fed these diets for 8 weeks and tested for the hypolipidemic bioactivity. Results: The fecal neutral cholesterol excretion was increased, and the serum total triglyceride (TG) was significantly reduced from 153.7mg/dL in the high-fat group (H) to 114.3119.8mg/dL by ASO; to 116.3147.9mg/dL by ASP; and to 116.2145.3mg/dL by ASH. Activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX) were almost unaffected. The high-density lipoprotein (HDL) levels were mostly raised by ASO to 180.3200.8mg/dL. The low-density lipoprotein (LDL) levels were mostly reduced to 66.882.6mg/dL by ASH. The level of arachidonic acid was mostly raised to 0.500.60% by ASO, compared with 0.37% of group H. More importantly, the significant reduction in hepatic TG and total cholesterol (TC) implicated a crucial liver protective effect. Discussion and conclusion: ASP and ASH consisted of high crude-fiber content, while ASO consisted of seed essential oil. Both the seed essential oil and the whole powder of AZ previously had been reported to possess potent hypolipidemic bioactivity. Conclusively, the hypolipidemic effect can be attributed to the combined effect of the essential oil and the crude fiber.

頁(從 - 到)1257-1264
期刊Pharmaceutical Biology
出版狀態已發佈 - 12月 2011

ASJC Scopus subject areas

  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學


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