Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia

Li Chen Lee, Li Wei, Wen Ching Huang, Yi Ju Hsu, Yi Ming Chen, Chi Chang Huang

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

Tomato is a globally famous food and contains several phytonutrients including lycopene,β-carotene, anthocyanin, and flavonoids. The increased temperature used to produce tomato juice, ketchup, tomato paste and canned tomato enhances the bioactive composition. We aimed to verify the beneficial effects of processed tomato juice from Kagome Ltd. (KOT) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups for treatment: normal (n = 8), standard diet (control); and experimental (n = 32), HCD. The 32 hamsters were further divided into four groups (n = 8 per group) to receive vehicle or KOT by oral gavage at 2787, 5573, or 13,934 mg/kg/day for six weeks, designated the HCD-1X, -2X and -5X groups, respectively. The efficacy and safety of KOT supplementation was evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. KOT supplementation dose-dependently decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. Our study provides experiment-based evidence to support that KOT may be useful in treating or preventing the onset of hyperlipidemia.
原文英語
頁(從 - 到)10525-10537
頁數13
期刊Nutrients
7
發行號12
DOIs
出版狀態已發佈 - 十二月 17 2015

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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    Lee, L. C., Wei, L., Huang, W. C., Hsu, Y. J., Chen, Y. M., & Huang, C. C. (2015). Hypolipidemic effect of tomato juice in hamsters in high cholesterol diet-induced hyperlipidemia. Nutrients, 7(12), 10525-10537. https://doi.org/10.3390/nu7125552