Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats

Ho Shan Niu, I. Min Liu, Juei Tang Cheng, Che Ling Lin, Feng Lin Hsu

研究成果: 雜誌貢獻文章

49 引文 (Scopus)

摘要

Eleutherococcus senticosus (Araliaceae) is a very powerful adaptogenic agent. In the present study, the effects of syringin, an active principle of this herb, on plasma glucose levels in streptozotocin-induced diabetic rats (STZ-diabetic rats) were investigated. Thirty minutes after syringin was intravenously injected into fasting STZ-diabetic rats, plasma glucose levels dose-dependently decreased. In normal rats, syringin at the effective dose (1.0 mg/kg) significantly attenuated the increase in plasma glucose caused by an intravenous glucose challenge. Syringin dose-dependently (0.01 to 10.0 μmol/L) stimulated glucose uptake in soleus muscle isolated from STZ-diabetic rats. Syringin treatment of hepatocytes isolated from STZ-diabetic rats enhanced glycogen synthesis. The ability of syringin to enhance glucose utilization and lower plasma glucose level in rats suffering from insulin deficiency suggest that this chemical may be useful in the treatment of human diabetes.
原文英語
頁(從 - 到)109-113
頁數5
期刊Planta Medica
74
發行號2
DOIs
出版狀態已發佈 - 二月 2008

指紋

Eleutherococcus
Eleutherococcus senticosus
glycemic effect
streptozotocin
Streptozocin
Hypoglycemic Agents
Rats
Glucose
glucose
rats
Plasmas
Araliaceae
dosage
Aptitude
Medical problems
syringin
Glycogen
hepatocytes
glycogen
fasting

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

引用此文

Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats. / Niu, Ho Shan; Liu, I. Min; Cheng, Juei Tang; Lin, Che Ling; Hsu, Feng Lin.

於: Planta Medica, 卷 74, 編號 2, 02.2008, p. 109-113.

研究成果: 雜誌貢獻文章

Niu, Ho Shan ; Liu, I. Min ; Cheng, Juei Tang ; Lin, Che Ling ; Hsu, Feng Lin. / Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats. 於: Planta Medica. 2008 ; 卷 74, 編號 2. 頁 109-113.
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AB - Eleutherococcus senticosus (Araliaceae) is a very powerful adaptogenic agent. In the present study, the effects of syringin, an active principle of this herb, on plasma glucose levels in streptozotocin-induced diabetic rats (STZ-diabetic rats) were investigated. Thirty minutes after syringin was intravenously injected into fasting STZ-diabetic rats, plasma glucose levels dose-dependently decreased. In normal rats, syringin at the effective dose (1.0 mg/kg) significantly attenuated the increase in plasma glucose caused by an intravenous glucose challenge. Syringin dose-dependently (0.01 to 10.0 μmol/L) stimulated glucose uptake in soleus muscle isolated from STZ-diabetic rats. Syringin treatment of hepatocytes isolated from STZ-diabetic rats enhanced glycogen synthesis. The ability of syringin to enhance glucose utilization and lower plasma glucose level in rats suffering from insulin deficiency suggest that this chemical may be useful in the treatment of human diabetes.

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