Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Sung Hsun Yu, Szu Yu Tina Chen, Wei Shan Li, Navneet Kumar Dubey, Wei Hong Chen, Jiunn Jye Chuu, Sy Jye Leu, Win Ping Deng

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed adverse effects; therefore, the Chinese herbal products are under investigation as an alternative treatment. In this study, a novel combination of fruiting body and mycelia powder of herbal Cordyceps militaris number 1 (CmNo1) was administered to evaluate their potential hypoglycemic effects in high-fat diet-(HFD-) induced type 2 DM in C57BL/6J mice. Body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and blood biochemistry indexes were measured. Results indicated that CmNo1 lowered the blood glucose level by increasing insulin sensitivity, while no change in body weight was observed. Increased protein expression of IRS-1, pIRS-1, AKT, pAKT, and GLUT-4 in skeletal muscle and adipose tissue was found indicating restoration of insulin signaling. Additionally, PPAR-γ expression in adipose tissue restored the triglyceride and cholesterol levels. Finally, our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.

原文英語
文章編號723190
期刊Journal of Diabetes Research
2015
DOIs
出版狀態已發佈 - 2015

指紋

Cordyceps
Mycelium
High Fat Diet
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Blood Glucose
Adipose Tissue
Diabetes Mellitus
Peroxisome Proliferator-Activated Receptors
Body Weight Changes
Glucose Tolerance Test
Inbred C57BL Mouse
Biochemistry
Powders
Insulin Resistance
Cause of Death
Fasting
Skeletal Muscle
Triglycerides
Cholesterol

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

引用此文

Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. / Yu, Sung Hsun; Chen, Szu Yu Tina; Li, Wei Shan; Dubey, Navneet Kumar; Chen, Wei Hong; Chuu, Jiunn Jye; Leu, Sy Jye; Deng, Win Ping.

於: Journal of Diabetes Research, 卷 2015, 723190, 2015.

研究成果: 雜誌貢獻文章

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abstract = "Diabetes mellitus (DM) is currently ranked among leading causes of death worldwide in which type 2 DM is reaching an epidemic proportion. Hypoglycemic medications for type 2 DM have either proven inadequate or posed adverse effects; therefore, the Chinese herbal products are under investigation as an alternative treatment. In this study, a novel combination of fruiting body and mycelia powder of herbal Cordyceps militaris number 1 (CmNo1) was administered to evaluate their potential hypoglycemic effects in high-fat diet-(HFD-) induced type 2 DM in C57BL/6J mice. Body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and blood biochemistry indexes were measured. Results indicated that CmNo1 lowered the blood glucose level by increasing insulin sensitivity, while no change in body weight was observed. Increased protein expression of IRS-1, pIRS-1, AKT, pAKT, and GLUT-4 in skeletal muscle and adipose tissue was found indicating restoration of insulin signaling. Additionally, PPAR-γ expression in adipose tissue restored the triglyceride and cholesterol levels. Finally, our results suggest that CmNo1 possesses strong hypoglycemic, anticholesterolemic, and antihypertriglyceridemic actions and is more economical alternate for DM treatment.",
author = "Yu, {Sung Hsun} and Chen, {Szu Yu Tina} and Li, {Wei Shan} and Dubey, {Navneet Kumar} and Chen, {Wei Hong} and Chuu, {Jiunn Jye} and Leu, {Sy Jye} and Deng, {Win Ping}",
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AU - Li, Wei Shan

AU - Dubey, Navneet Kumar

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