Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2

D. T. Ju, J. W. Lin, M. S. Lin, L. M. Lee, H. M. Tseng, C. P. Wei, C. H. Yen, C. C. Hung, K. S. Hung, C. M. Lin, Tien-Jen Lin, W. T. Chiu, Jo Ting Tsai

研究成果: 書貢獻/報告類型章節

19 引文 斯高帕斯(Scopus)

摘要

CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.

原文英語
主出版物標題Reconstructive Neurosurgery
發行者Springer-Verlag Wien
頁面169-173
頁數5
版本101
ISBN(列印)9783211782040
DOIs
出版狀態已發佈 - 一月 1 2008

出版系列

名字Acta Neurochirurgica, Supplementum
號碼101
ISSN(列印)0065-1419

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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