CyberKnife stereotactic radiosurgery (CKSRS) has been proved effective in treating intra-cranial lesions. To treat acoustic neuroma (AN) patients with or without neurofibromatosis Type 2 (NF2) associations, the functional preservation of hearing, trigeminal nerve, and facial nerve are important. Twenty-one patients were treated with hypofractionated CKSRS. Fourteen non-NF2 and seven NF2 patients were enrolled. Cranial nerve function, audiograms, and magnetic resonance images (MRI) were monitored. Mean follow-up was 15 month. Tumors with volumes ranging from 0.13 to 24.8 cm3 (mean 5.4 cm3) were irradiated with the marginal dose 1800-2000 cGy/3 fractions. Tumors were treated with an 80 to 89% isodose line (mean 83%) and mean 97.9% tumor coverage. Two patients experienced hearing deterioration (16.7%) in the non-NF2 group, and 3 patients (50%) in the NF2 group. No facial or trigeminal dysfunction, brain stem toxicity, or cerebellar edema occurred. Tumor regression was seen in 9 patients (43%) and stable in 12 patients (57%). 100% tumor control rate was achieved. Hypofractionated CKSRS was not only effective in tumor control but also excellent in hearing preservation for non-NF2 AN. But for NF2 patients, although the tumor control was remarkable, hearing preservation was modest as in non-NF2 patients.
|主出版物標題||Acta Neurochirurgica, Supplementum|
|出版狀態||已發佈 - 2008|
|名字||Acta Neurochirurgica, Supplementum|
ASJC Scopus subject areas
- Clinical Neurology
Ju, D. T., Lin, J. W., Lin, M. S., Lee, L. M., Tseng, H. M., Wei, C. P., Yen, C. H., Hung, C. C., Hung, K. S., Lin, C. M., Lin, T. J., Chiu, W. T., & Tsai, J. T. (2008). Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. 於 Acta Neurochirurgica, Supplementum (101 編輯, 頁 169-173). (Acta Neurochirurgica, Supplementum; 編號 101). https://doi.org/10.1007/978-3-211-78205-7-29