HYpertonicity increases rabbit atrium and pulmonary vein arrhythmogenesis: A potential Contributor to the genesis of atrial fibrillation

Shih Huang Lee, Yao Chang Chen, Chen Chuan Cheng, Satoshi Higa, Yi Jen Chen, Shih Ann Chen

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Pulmonary veins are the most important focus for the initiation of atrial fibrillation. Diabetes mellitus may be associated with hypertonicity and increased occurrence of atrial fibrillation. The purpose of the present study was to investigate whether hypertonicity alters the electrophysiological characteristics of pulmonary veins and atria to enhance the genesis of atrial fibrillation. A whole-cell patch-clamp technique was used to investigate action potentials and ionic currents in rabbit isolated single pulmonary vein and atrial cardiomyocytes during immersion in isotonic and hypertonic (1.2× normal osmolality) solutions. Hypertonicity increased the spontaneous beating rates of pulmonary vein cardiomyocytes from 2.3 ± 0.3 to 3.4 ± 0.3 Hz (n = 11; P <0.001). Hypertonicity prolonged action potential duration to a greater extent in atrial cardiomyocytes than in pulmonary vein cardiomyocytes. Compared with atrial cardiomyocytes, hypertonicity increased the transient inward currents and Na +/Ca 2+ exchange currents to a greater extent in pulmonary vein cardiomyocytes, but decreased the delayed rectified potassium currents to a lesser extent. Hypertonicity plays an important role in the electrical activity of pulmonary vein and atrial cardiomyocytes, which may have a potential role in the pathophysiology of atrial fibrillation.

原文英語
頁(從 - 到)419-424
頁數6
期刊Clinical and Experimental Pharmacology and Physiology
36
發行號4
DOIs
出版狀態已發佈 - 四月 2009

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

指紋 深入研究「HYpertonicity increases rabbit atrium and pulmonary vein arrhythmogenesis: A potential Contributor to the genesis of atrial fibrillation」主題。共同形成了獨特的指紋。

  • 引用此