摘要

BACKGROUND AND PURPOSE-: Case reports or case series have reported the association between hyperthyroidism and cerebrovascular disease. However, hyperthyroidism has never been considered as a potential risk factor for stroke in young people. The aim of the present study is to estimate the risk for ischemic stroke among hyperthyroidism patients aged 18 to 44 years during a 5-year period after the diagnosis of hyperthyroidism as compared to a cohort of patients without hyperthyroidism during the same period. METHODS-: A total of 3176 patients with hyperthyroidism were included as the study cohort and 25 408 patients without hyperthyroidism were included as comparison cohort. Each patient was individually tracked for 5 years from their index ambulatory visit to identify those in whom ischemic stroke developed. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rate between these 2 cohorts. RESULTS-: Of the total sample of 28 584 patients, 198 patients (0.7%) had ischemic strokes during the 5-year follow-up period (31 [1.0% of the hyperthyroidism patients] from the study cohort and 167 [0.6% of comparison patients] from the comparison cohort). After adjusting for the patientÊ's age, gender, income, level of urbanization, hypertension, diabetes, atrial fibrillation, hyperlipidemia, coronary heart disease, and whether they were using antiarrhythmics, the hazard of having ischemic stroke during the 5-year follow-up period was 1.44-times greater (95% CI, 1.02-2.12; P=0.038) for patients with hyperthyroidism than for patients in the comparison cohort. CONCLUSIONS-: We conclude that hyperthyroidism is associated with an increased risk for ischemic stroke among young adults.
原文英語
頁(從 - 到)961-966
頁數6
期刊Stroke
41
發行號5
DOIs
出版狀態已發佈 - 五月 2010

指紋

Hyperthyroidism
Young Adult
Stroke
Cohort Studies
Cerebrovascular Disorders
Urbanization
Hyperlipidemias
Atrial Fibrillation
Coronary Disease
Survival Rate
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

引用此文

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title = "Hyperthyroidism and risk of ischemic stroke in young adults: A 5-year follow-up study",
abstract = "BACKGROUND AND PURPOSE-: Case reports or case series have reported the association between hyperthyroidism and cerebrovascular disease. However, hyperthyroidism has never been considered as a potential risk factor for stroke in young people. The aim of the present study is to estimate the risk for ischemic stroke among hyperthyroidism patients aged 18 to 44 years during a 5-year period after the diagnosis of hyperthyroidism as compared to a cohort of patients without hyperthyroidism during the same period. METHODS-: A total of 3176 patients with hyperthyroidism were included as the study cohort and 25 408 patients without hyperthyroidism were included as comparison cohort. Each patient was individually tracked for 5 years from their index ambulatory visit to identify those in whom ischemic stroke developed. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rate between these 2 cohorts. RESULTS-: Of the total sample of 28 584 patients, 198 patients (0.7{\%}) had ischemic strokes during the 5-year follow-up period (31 [1.0{\%} of the hyperthyroidism patients] from the study cohort and 167 [0.6{\%} of comparison patients] from the comparison cohort). After adjusting for the patient{\^E}'s age, gender, income, level of urbanization, hypertension, diabetes, atrial fibrillation, hyperlipidemia, coronary heart disease, and whether they were using antiarrhythmics, the hazard of having ischemic stroke during the 5-year follow-up period was 1.44-times greater (95{\%} CI, 1.02-2.12; P=0.038) for patients with hyperthyroidism than for patients in the comparison cohort. CONCLUSIONS-: We conclude that hyperthyroidism is associated with an increased risk for ischemic stroke among young adults.",
keywords = "Hyperthyroidism, Ischemic stroke",
author = "Lin, {Herng Ching} and Sheu, {Jau Jiuan} and Kang, {Jiunn Horng} and Lin, {Hsiu Chen}",
year = "2010",
month = "5",
doi = "10.1161/STROKEAHA.109.577742",
language = "English",
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pages = "961--966",
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number = "5",

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TY - JOUR

T1 - Hyperthyroidism and risk of ischemic stroke in young adults

T2 - A 5-year follow-up study

AU - Lin, Herng Ching

AU - Sheu, Jau Jiuan

AU - Kang, Jiunn Horng

AU - Lin, Hsiu Chen

PY - 2010/5

Y1 - 2010/5

N2 - BACKGROUND AND PURPOSE-: Case reports or case series have reported the association between hyperthyroidism and cerebrovascular disease. However, hyperthyroidism has never been considered as a potential risk factor for stroke in young people. The aim of the present study is to estimate the risk for ischemic stroke among hyperthyroidism patients aged 18 to 44 years during a 5-year period after the diagnosis of hyperthyroidism as compared to a cohort of patients without hyperthyroidism during the same period. METHODS-: A total of 3176 patients with hyperthyroidism were included as the study cohort and 25 408 patients without hyperthyroidism were included as comparison cohort. Each patient was individually tracked for 5 years from their index ambulatory visit to identify those in whom ischemic stroke developed. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rate between these 2 cohorts. RESULTS-: Of the total sample of 28 584 patients, 198 patients (0.7%) had ischemic strokes during the 5-year follow-up period (31 [1.0% of the hyperthyroidism patients] from the study cohort and 167 [0.6% of comparison patients] from the comparison cohort). After adjusting for the patientÊ's age, gender, income, level of urbanization, hypertension, diabetes, atrial fibrillation, hyperlipidemia, coronary heart disease, and whether they were using antiarrhythmics, the hazard of having ischemic stroke during the 5-year follow-up period was 1.44-times greater (95% CI, 1.02-2.12; P=0.038) for patients with hyperthyroidism than for patients in the comparison cohort. CONCLUSIONS-: We conclude that hyperthyroidism is associated with an increased risk for ischemic stroke among young adults.

AB - BACKGROUND AND PURPOSE-: Case reports or case series have reported the association between hyperthyroidism and cerebrovascular disease. However, hyperthyroidism has never been considered as a potential risk factor for stroke in young people. The aim of the present study is to estimate the risk for ischemic stroke among hyperthyroidism patients aged 18 to 44 years during a 5-year period after the diagnosis of hyperthyroidism as compared to a cohort of patients without hyperthyroidism during the same period. METHODS-: A total of 3176 patients with hyperthyroidism were included as the study cohort and 25 408 patients without hyperthyroidism were included as comparison cohort. Each patient was individually tracked for 5 years from their index ambulatory visit to identify those in whom ischemic stroke developed. Cox proportional hazard regressions were performed to compute the 5-year stroke-free survival rate between these 2 cohorts. RESULTS-: Of the total sample of 28 584 patients, 198 patients (0.7%) had ischemic strokes during the 5-year follow-up period (31 [1.0% of the hyperthyroidism patients] from the study cohort and 167 [0.6% of comparison patients] from the comparison cohort). After adjusting for the patientÊ's age, gender, income, level of urbanization, hypertension, diabetes, atrial fibrillation, hyperlipidemia, coronary heart disease, and whether they were using antiarrhythmics, the hazard of having ischemic stroke during the 5-year follow-up period was 1.44-times greater (95% CI, 1.02-2.12; P=0.038) for patients with hyperthyroidism than for patients in the comparison cohort. CONCLUSIONS-: We conclude that hyperthyroidism is associated with an increased risk for ischemic stroke among young adults.

KW - Hyperthyroidism

KW - Ischemic stroke

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