Hyperthermia Potentiates Doxorubicin-Related Cardiotoxic Effects

Young Duk Kim, David Eric Lees, Charles R. Lake, Jacqueline Whang-Peng, Joan Bull, William Schuette, Rosalie Smith

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)


The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.
頁(從 - 到)1816-1817
期刊JAMA: The Journal of the American Medical Association
出版狀態已發佈 - 四月 27 1979

ASJC Scopus subject areas

  • Medicine(all)

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