Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy

Ko Jie Chen, Er Yuan Chaung, Shiaw Pyng Wey, Kun Ju Lin, Felice Cheng, Chia Chen Lin, Hao Li Liu, Hsiang Wen Tseng, Chih Peng Liu, Ming Cheng Wei, Chun Min Liu, Hsing Wen Sung

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138 引文 斯高帕斯(Scopus)

摘要

As is widely suspected, lysolipid dissociation from liposomes contributes to the intravenous instability of ThermoDox (lysolipid liposomes), thereby impeding its antitumor efficacy. This work evaluates the feasibility of a thermoresponsive bubble-generating liposomal system without lysolipids for tumor-specific chemotherapy. The key component in this liposomal formulation is its encapsulated ammonium bicarbonate (ABC), which is used to actively load doxorubicin (DOX) into liposomes and trigger a drug release when heated locally. Incubating ABC liposomes with whole blood results in a significantly smaller decrease in the retention of encapsulated DOX than that by lysolipid liposomes, indicating superior plasma stability. Biodistribution analysis results indicate that the ABC formulation circulates longer than its lysolipid counterpart. Following the injection of ABC liposome suspension into mice with tumors heated locally, decomposition of the ABC encapsulated in liposomes facilitates the immediate thermal activation of CO2 bubble generation, subsequently increasing the intratumoral DOX accumulation. Consequently, the antitumor efficacy of the ABC liposomes is superior to that of their lysolipid counterparts. Results of this study demonstrate that this thermoresponsive bubble-generating liposomal system is a highly promising carrier for tumor-specific chemotherapy, especially for local drug delivery mediated at hyperthermic temperatures.
原文英語
頁(從 - 到)5105-5115
頁數11
期刊ACS Nano
8
發行號5
DOIs
出版狀態已發佈 - 5月 27 2014
對外發佈

ASJC Scopus subject areas

  • 材料科學(全部)
  • 工程 (全部)
  • 物理與天文學 (全部)

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