Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis

Chi-Hua Chen, Chun-Bing Chen, Chee Jen Chang, Yu Jr Lin, Chuang-Wei Wang, Ching-Chi Chi, Chun-Wei Lu, Wei-Ti Chen, Ren-You Pan, Shih-Chi Su, Lung-An Hsu, Ya-Ching Chang, Kuang-Hui Yu, Yeong-Jian Jan Wu, Ko-Ming Lin, Shuen-Iu Hung, Shin-Ming Chen, Wen-Hung Chung

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14 引文 斯高帕斯(Scopus)

摘要

The safety of newer xanthine oxidase inhibitor-febuxostat comparing to allopurinol remains unclear. To compare the risks of allopurinol- and febuxostat-hypersensitivity and cardiovascular diseases (CVD) in Asians, we conducted a population-based cohort study enrolling patients receiving allopurinol or febuxostat from Chang Gung Memorial Hospital Health System across Taiwan during 2012-2016 and further performed a meta-analysis incorporating two recent studies. Among the 61,539 users, a corresponding 12,007 and 5,680 patients were identified as new users. The overall incidence of febuxostat-hypersensitivity was significantly lower than allopurinol-hypersensitivity (0.2v.s.2.7 per 1000 new users, P<0.001). There were 33 allopurinol-hypersensitivity (including 18 severe cutaneous adverse drug reactions) and only one patient developed febuxostat-maculopapular exanthema. Moreover, febuxostat was not statistically increased risk of CVD (HR,1.16; P=0.152) and related death (HR,1.49; P=0.496) compared to allopurinol. The result of meta-analysis also showed consistent result. In conclusion, the incidence and severity of febuxostat-hypersensitivity are lower than with allopurinol. Febuxostat didn't show an increased risk of CVD and related death. This article is protected by copyright. All rights reserved.
原文英語
頁(從 - 到)391-401
頁數11
期刊Clinical Pharmacology and Therapeutics
106
發行號2
早期上線日期一月 28 2019
DOIs
出版狀態已發佈 - 八月 2019

ASJC Scopus subject areas

  • 藥學(醫學)
  • 藥理

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