Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure

K. C. Lu; S. D. Shieh; S. H. Lin; S. H. Chyr; Y. F. Lin; L. K. Diang; B. L. Li; W. H H Sheu; Y. A. Ding

Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure

K. C. Lu, S. D. Shieh, S. H. Lin, S. H. Chyr, Y. F. Lin, L. K. Diang, B. L. Li, W. H H Sheu, Y. A. Ding

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摘要

Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca²⁺](i)), and glucose tolerance in chronic renal failure, we measured serum intact PTH (I-PTH) by two-site immunometric assay, platelet [Ca²⁺](i), using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum I-PTH. Calcitriol (1 μg) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum I-PTH (p2+](i), (p

原文	英語
頁（從 - 到）	359-365
頁數	7
期刊	Quarterly Journal of Medicine
卷	87
發行號	6
出版狀態	已發佈 - 1994
對外發佈	是

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abstract = "Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca2+](i)), and glucose tolerance in chronic renal failure, we measured serum intact PTH (I-PTH) by two-site immunometric assay, platelet [Ca2+](i), using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum I-PTH. Calcitriol (1 μg) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum I-PTH (p2+](i), (p",

author = "Lu, {K. C.} and Shieh, {S. D.} and Lin, {S. H.} and Chyr, {S. H.} and Lin, {Y. F.} and Diang, {L. K.} and Li, {B. L.} and Sheu, {W. H H} and Ding, {Y. A.}",

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AU - Shieh, S. D.

AU - Lin, S. H.

AU - Chyr, S. H.

AU - Lin, Y. F.

AU - Diang, L. K.

AU - Li, B. L.

AU - Sheu, W. H H

AU - Ding, Y. A.

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Hyperparathyroidism, glucose tolerance and platelet intracellular free calcium in chronic renal failure

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