摘要
Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. To investigate possible relationships between hyperparathyroidism, intracellular free calcium ([Ca2+](i)), and glucose tolerance in chronic renal failure, we measured serum intact PTH (I-PTH) by two-site immunometric assay, platelet [Ca2+](i), using the fluorescent indicator fura-2, and plasma glucose and insulin after 14 h overnight fast and at 30, 60 and 120 min following a 75 g oral glucose load, in 18 chronic haemodialysis patients with elevated serum I-PTH. Calcitriol (1 μg) was administered parenterally at the end of each dialysis session for four weeks. This significantly decreased serum I-PTH (p2+](i), (p
原文 | 英語 |
---|---|
頁(從 - 到) | 359-365 |
頁數 | 7 |
期刊 | Quarterly Journal of Medicine |
卷 | 87 |
發行號 | 6 |
出版狀態 | 已發佈 - 1994 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 醫藥 (全部)