Hyperleptinemia is associated with the aortic augmentation index in kidney transplant recipients

Yen Cheng Chen, Ming Che Lee, Chung Jen Lee, Bang Gee Hsu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Objective: Increased circulating leptin, a marker of leptin resistance, is common in patients with obesity and is also an independent factor in prediction of cardiovascular disease. The aim of this study was to evaluate the relationship between fasting serum leptin levels and the aortic augmentation index (AIx) in kidney transplant recipients. Materials and Methods: Fasting blood samples were obtained from 70 kidney transplant recipients. The aortic AIx was measured using a validated tonometry system (SphygmoCor). Plasma leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Results: Simple linear analysis of the aortic AIx in kidney transplant recipients showed that body fat mass (P = 0.002), diastolic blood pressure (DBP) (P = 0.020), logarithmically transformed triglycerides (P = 0.035), and leptin (P < 0.001) were positively correlated, while height (P = 0.004) and the glomerular filtration rate (P = 0.022) were negatively correlated with the aortic AIx in kidney transplant recipients. Forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx showed that leptin (P < 0.001), DBP (P = 0.014), and body height (P = 0.036) were independent predictors of the aortic AIx in kidney transplant recipients. Conclusion: These results suggest that the serum fasting leptin level is associated with the aortic AIx in kidney transplant recipients.

原文英語
頁(從 - 到)152-157
頁數6
期刊Tzu Chi Medical Journal
30
發行號3
DOIs
出版狀態已發佈 - 7月 1 2018
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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