To the Editor: Bunn et al. comment that the presence of retrovirus-associated T-cell lymphomas should be strongly suspected on clinical grounds in patients who present with hypercalcemia and metabolic bone abnormalities (Aug. 4 issue).1 In August 1983, we evaluated a 29-year-old white man with painful lytic bone lesions, refractory hypercalcemia (16.0 mg per deciliter), and leukocytosis (53,000 per microliter); 42 percent of the circulating cells resembled poorly differentiated lymphoma cells with marked nuclear clefting and folding. Eleven years earlier the patient had received total-nodal irradiation for Hodgkin's disease (nodular sclerosing), followed two years later by MOPP (mechlorethamine, vincristine, procarbazine,.
ASJC Scopus subject areas
- 醫藥 (全部)