Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon

Y. Takada, N. Kaneko, H. Esumi, P. E. Purdue, C. J. Danpure

研究成果: 雜誌貢獻文章同行評審

105 引文 斯高帕斯(Scopus)

摘要

The amino acid sequence of human hepatic peroxisomal L-alanine:glyoxylate aminotransferase 1 (AGT1) deduced from cDNA shows 78% sequence identity with that of rat mitochondrial AGT1, but lacks the N-terminal 22 amino acids (the putative mitochondrial targeting signal). In humans this signal appears to have been depleted during evolution by a point mutation of the initiation codon ATG to ATA. These data suggest that the targeting defect in primary hyperoxaluria type 1, in which AGT1 is diverted from the peroxisomes to the mitochondria, could be due to a point mutation that reintroduces all or part of the mitochondrial signal sequence.

原文英語
頁(從 - 到)517-520
頁數4
期刊Biochemical Journal
268
發行號2
出版狀態已發佈 - 1990
對外發佈

ASJC Scopus subject areas

  • 生物化學

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