Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results

Ming Guo, Ching Yu Lin, Yun Gong, David E. Cogdell, Wei Zhang, E. Lin, Nour Sneige

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

摘要

To evaluate whether human papillomavirus (HPV) genotyping for the selected oncogenic HPV types can improve the efficacy of HPV DNA testing in predicting cervical intraepithelial neoplasia (CIN 2/3) in women with mildly abnormal Pap results, we compared HPV DNA testing and HPV genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in Pap specimens with abnormal results (HSIL, 20 cases; LSIL, 42 cases; ASC-US, 94 cases) and follow-up biopsies. Using consensus primer-mediated PCR assays, HPV DNA was detected in 90% (18/20) of HSIL, 95% (40/42) of LSIL and 64% (60/94) of ASC-US cases. HPV DNA positivity was significantly associated with CIN 2/3/carcinoma (P
原文英語
頁(從 - 到)1037-1043
頁數7
期刊Modern Pathology
21
發行號8
DOIs
出版狀態已發佈 - 八月 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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