Human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities: A two-year follow-up report

Lee Wen Huang, Yu Hung Lin, Hun Shan Pan, Kok Min Seow, Ching Yu Lin

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

High-risk human papillomavirus (HR-HPV) DNA testing has emerged as another testing modality for women with mildly cytologic abnormalities. We conducted a two-year follow-up study of 108 women with mildly abnormal cervical cytology for detection of CIN 2/3. A cervical swab sample was obtained for HPV genotyping by a HPV blot and histologic follow-up results were correlated with HR-HPV types. Of the 108 cases, 93 (86.1%) were positive for HR-HPV DNA. HPV-16 was detected in 45.1% of patients. CIN grade 2 or 3 was confirmed in 25 (23.1%) of the 108 women during the two-year follow-up period. The two-year cumulative incidence rates of CIN 2/3 were 38.6% (17/44) among HPV-16- positive women, but only 5.6% among HR-HPV-positive women without HPV-16 or HPV-18. The sensitivity of a positive HPV-16 test for CIN 2/3 was 68.0%, the specificity was 67.5%. Our results demonstrated that the type-specific HPV-16 test increased sensitivity of detecting high-grade cervical dysplasia for women who have mildly cytologic abnormalities. The implication of the present findings is that HPV genotyping may identify women with the greatest risk of high-grade CIN.
原文英語
頁(從 - 到)673-677
頁數5
期刊Diagnostic Cytopathology
40
發行號8
DOIs
出版狀態已發佈 - 八月 2012

指紋

Uterine Cervical Dysplasia
Human papillomavirus 16
Human papillomavirus 18
DNA
Cell Biology
Incidence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

引用此文

Human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities : A two-year follow-up report. / Huang, Lee Wen; Lin, Yu Hung; Pan, Hun Shan; Seow, Kok Min; Lin, Ching Yu.

於: Diagnostic Cytopathology, 卷 40, 編號 8, 08.2012, p. 673-677.

研究成果: 雜誌貢獻文章

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abstract = "High-risk human papillomavirus (HR-HPV) DNA testing has emerged as another testing modality for women with mildly cytologic abnormalities. We conducted a two-year follow-up study of 108 women with mildly abnormal cervical cytology for detection of CIN 2/3. A cervical swab sample was obtained for HPV genotyping by a HPV blot and histologic follow-up results were correlated with HR-HPV types. Of the 108 cases, 93 (86.1{\%}) were positive for HR-HPV DNA. HPV-16 was detected in 45.1{\%} of patients. CIN grade 2 or 3 was confirmed in 25 (23.1{\%}) of the 108 women during the two-year follow-up period. The two-year cumulative incidence rates of CIN 2/3 were 38.6{\%} (17/44) among HPV-16- positive women, but only 5.6{\%} among HR-HPV-positive women without HPV-16 or HPV-18. The sensitivity of a positive HPV-16 test for CIN 2/3 was 68.0{\%}, the specificity was 67.5{\%}. Our results demonstrated that the type-specific HPV-16 test increased sensitivity of detecting high-grade cervical dysplasia for women who have mildly cytologic abnormalities. The implication of the present findings is that HPV genotyping may identify women with the greatest risk of high-grade CIN.",
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