One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
ASJC Scopus subject areas
- Molecular Medicine
Wang, S. F., Chen, K. H., Chen, M., Li, W. Y., Chen, Y. J., Tsao, C. H., Yen, M. Y., Huang, J. C., & Chen, Y. M. A. (2011). Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection. Viral Immunology, 24(5), 421-426. https://doi.org/10.1089/vim.2011.0024