Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang, Kuan Hsuan Chen, Marcelo Chen, Wen Yi Li, Yen Ju Chen, Ching Han Tsao, Muh Yong Yen, Jason C. Huang, Yi Ming Arthur Chen

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
原文英語
頁(從 - 到)421-426
頁數6
期刊Viral Immunology
24
發行號5
DOIs
出版狀態已發佈 - 十月 1 2011
對外發佈Yes

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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