Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients

Hsien Tzung Liao, Kuan Chia Lin, Yun Ting Chang, Chun Hsiung Chen, Toong Hua Liang, Wei Sheng Chen, Kuei Ying Su, Chang Youh Tsai, Chung Tei Chou

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

摘要

Objective. Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To date, no study has compared the differences of genes between patients with PsA and psoriasis and healthy controls in a Chinese population. We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. Methods. HLA studies were performed using polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with psoriasis and 75 controls. Age at disease onset, sex, disease duration, enthesitis, and uveitis were also analyzed. Results. Among the patients with PsA and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the prevalence of HLA-DR*17 was significantly higher in controls than in those with psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p <0.05). Among PsA patients, the association between HLA-B*27 and axial joint involvement and uveitis was significant (p <0.05). Conclusion. Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, - DR*07) and PsA (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first study to assess the genetic role of HLA in patients with psoriasis and PsA in a Chinese population.

原文英語
頁(從 - 到)891-895
頁數5
期刊Journal of Rheumatology
35
發行號5
出版狀態已發佈 - 五月 2008

    指紋

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

引用此

Liao, H. T., Lin, K. C., Chang, Y. T., Chen, C. H., Liang, T. H., Chen, W. S., Su, K. Y., Tsai, C. Y., & Chou, C. T. (2008). Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients. Journal of Rheumatology, 35(5), 891-895.