Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients

Hsien Tzung Liao, Kuan Chia Lin, Yun Ting Chang, Chun Hsiung Chen, Toong Hua Liang, Wei Sheng Chen, Kuei Ying Su, Chang Youh Tsai, Chung Tei Chou

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Objective. Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To date, no study has compared the differences of genes between patients with PsA and psoriasis and healthy controls in a Chinese population. We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. Methods. HLA studies were performed using polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with psoriasis and 75 controls. Age at disease onset, sex, disease duration, enthesitis, and uveitis were also analyzed. Results. Among the patients with PsA and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the prevalence of HLA-DR*17 was significantly higher in controls than in those with psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p <0.05). Among PsA patients, the association between HLA-B*27 and axial joint involvement and uveitis was significant (p <0.05). Conclusion. Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, - DR*07) and PsA (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first study to assess the genetic role of HLA in patients with psoriasis and PsA in a Chinese population.

原文英語
頁(從 - 到)891-895
頁數5
期刊Journal of Rheumatology
35
發行號5
出版狀態已發佈 - 五月 2008

指紋

Psoriatic Arthritis
HLA Antigens
Psoriasis
Demography
Uveitis
Alleles
Age of Onset
Oligonucleotides

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

引用此文

Liao, H. T., Lin, K. C., Chang, Y. T., Chen, C. H., Liang, T. H., Chen, W. S., ... Chou, C. T. (2008). Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients. Journal of Rheumatology, 35(5), 891-895.

Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients. / Liao, Hsien Tzung; Lin, Kuan Chia; Chang, Yun Ting; Chen, Chun Hsiung; Liang, Toong Hua; Chen, Wei Sheng; Su, Kuei Ying; Tsai, Chang Youh; Chou, Chung Tei.

於: Journal of Rheumatology, 卷 35, 編號 5, 05.2008, p. 891-895.

研究成果: 雜誌貢獻文章

Liao, HT, Lin, KC, Chang, YT, Chen, CH, Liang, TH, Chen, WS, Su, KY, Tsai, CY & Chou, CT 2008, 'Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients', Journal of Rheumatology, 卷 35, 編號 5, 頁 891-895.
Liao, Hsien Tzung ; Lin, Kuan Chia ; Chang, Yun Ting ; Chen, Chun Hsiung ; Liang, Toong Hua ; Chen, Wei Sheng ; Su, Kuei Ying ; Tsai, Chang Youh ; Chou, Chung Tei. / Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients. 於: Journal of Rheumatology. 2008 ; 卷 35, 編號 5. 頁 891-895.
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title = "Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients",
abstract = "Objective. Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To date, no study has compared the differences of genes between patients with PsA and psoriasis and healthy controls in a Chinese population. We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. Methods. HLA studies were performed using polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with psoriasis and 75 controls. Age at disease onset, sex, disease duration, enthesitis, and uveitis were also analyzed. Results. Among the patients with PsA and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the prevalence of HLA-DR*17 was significantly higher in controls than in those with psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p <0.05). Among PsA patients, the association between HLA-B*27 and axial joint involvement and uveitis was significant (p <0.05). Conclusion. Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, - DR*07) and PsA (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first study to assess the genetic role of HLA in patients with psoriasis and PsA in a Chinese population.",
keywords = "Genetic study, Human leukocyte antigen, Psoriasis, Psoriatic arthritis",
author = "Liao, {Hsien Tzung} and Lin, {Kuan Chia} and Chang, {Yun Ting} and Chen, {Chun Hsiung} and Liang, {Toong Hua} and Chen, {Wei Sheng} and Su, {Kuei Ying} and Tsai, {Chang Youh} and Chou, {Chung Tei}",
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TY - JOUR

T1 - Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients

AU - Liao, Hsien Tzung

AU - Lin, Kuan Chia

AU - Chang, Yun Ting

AU - Chen, Chun Hsiung

AU - Liang, Toong Hua

AU - Chen, Wei Sheng

AU - Su, Kuei Ying

AU - Tsai, Chang Youh

AU - Chou, Chung Tei

PY - 2008/5

Y1 - 2008/5

N2 - Objective. Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To date, no study has compared the differences of genes between patients with PsA and psoriasis and healthy controls in a Chinese population. We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. Methods. HLA studies were performed using polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with psoriasis and 75 controls. Age at disease onset, sex, disease duration, enthesitis, and uveitis were also analyzed. Results. Among the patients with PsA and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the prevalence of HLA-DR*17 was significantly higher in controls than in those with psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p <0.05). Among PsA patients, the association between HLA-B*27 and axial joint involvement and uveitis was significant (p <0.05). Conclusion. Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, - DR*07) and PsA (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first study to assess the genetic role of HLA in patients with psoriasis and PsA in a Chinese population.

AB - Objective. Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To date, no study has compared the differences of genes between patients with PsA and psoriasis and healthy controls in a Chinese population. We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. Methods. HLA studies were performed using polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with psoriasis and 75 controls. Age at disease onset, sex, disease duration, enthesitis, and uveitis were also analyzed. Results. Among the patients with PsA and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the prevalence of HLA-DR*17 was significantly higher in controls than in those with psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p <0.05). Among PsA patients, the association between HLA-B*27 and axial joint involvement and uveitis was significant (p <0.05). Conclusion. Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, - DR*07) and PsA (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first study to assess the genetic role of HLA in patients with psoriasis and PsA in a Chinese population.

KW - Genetic study

KW - Human leukocyte antigen

KW - Psoriasis

KW - Psoriatic arthritis

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