Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2

Xin Chen, Shau ching Wen, Michiko N. Fukuda, Narender R. Gavva, Duen wei Hsu, Tomoya O. Akama, Teresa Yang-Feng, C. K.James Shen

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

We have cloned a new protein that interacts with the hematopoietic DNA-binding transcription factor, p45/NF-E2, by screening a human erythroleukemia cell cDNA library with the yeast two-hybrid approach. Predicted peptide sequence and chromosomal mapping identified the cloned molecule to be the product of the human ortholog of the mouse Itch gene, which has been implicated previously in the regulation of growth and differentiation of erythroid and lymphoid cells. Transfection experiments indicate that this human ITCH protein can act as a transcriptional corepressor of p45/NF-E2. Our data provide novel insights into the functional roles of the mammalian ITCH proteins in the development of hematopoietic cell lineages.

原文英語
頁(從 - 到)238-241
頁數4
期刊Genomics
73
發行號2
DOIs
出版狀態已發佈 - 4月 15 2001
對外發佈

ASJC Scopus subject areas

  • 遺傳學

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