Human DExD/H RNA helicases: Emerging roles in stress survival regulation

Jing Wen Shih, Yan Hwa Wu Lee

研究成果: 雜誌貢獻回顧型文獻同行評審

22 引文 斯高帕斯(Scopus)

摘要

Environmental stresses threatening cell homeostasis trigger various cellular responses ranging from the activation of survival pathways to eliciting programmed cell death. Cellular stress response highly depends on the nature and level of the insult as well as the cell type. Notably, the interplay among all these responses will ultimately determine the fate of the stressed cell. Human DExD/H RNA helicases are ubiquitous molecular motors rearranging RNA secondary structure in an ATP-dependent fashion. These highly conserved enzymes participate in nearly all aspects of cellular process involving RNA metabolism. Although numerous functions of DExD/H RNA helicases are well documented, their importance in stress response is only just becoming evident. This review outlines our current knowledge on major mechanistic themes of human DExD/H RNA helicases in response to stressful stimuli, especially on emerging molecular models for the functional roles of these enzymes in the stress survival regulation.
原文英語
頁(從 - 到)45-58
頁數14
期刊Clinica Chimica Acta
436
DOIs
出版狀態已發佈 - 九月 25 2014

ASJC Scopus subject areas

  • 生物化學
  • 臨床生物化學
  • 生物化學(醫學)

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