Human chromosomal centromere (AATGG)n sequence forms stable structures with unusual base pairs

T. N. Jaishree, Andrew H.J. Wang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Nine DNA sequences related to the purine strand of the human centromeric satellite (AATGG)n·(CCAAT)n repeat have been studied by two-dimensional nuclear magnetic resonance spectroscopy. Earlier studies have suggested that the structure of (AATGG)n sequence has an equilibrium between the duplex form and a fold-back form. Structural refinement of d(CAATGG) and its related sequences by an NOE-constrained simulated annealing procedure reveals that the duplex form incorporates dynamic type-I G-A base pairs. 1D exchangeable proton NMR data support this model. The reverse sequence motif (GGTAA) destabilizes the structure.

原文英語
頁(從 - 到)99-103
頁數5
期刊FEBS Letters
347
發行號1
DOIs
出版狀態已發佈 - 6月 20 1994
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

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