HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

HIN‐WING ‐W YEUNG, DONALD YAMASHIRO, LIANG‐FU ‐F TSENG, WEN‐CHANG ‐C CHANG, CHOH HAO LI

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.
原文英語
頁(從 - 到)235-238
頁數4
期刊International Journal of Peptide and Protein Research
17
發行號2
DOIs
出版狀態已發佈 - 一月 1 1981
對外發佈Yes

指紋

Endorphins
Bioactivity
Substitution reactions
Assays
Opioid Peptides
Ileum
Analgesics
Guinea Pigs

ASJC Scopus subject areas

  • Biochemistry

引用此文

HUMAN β‐ENDORPHIN : SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31. / YEUNG, HIN‐WING ‐W; YAMASHIRO, DONALD; TSENG, LIANG‐FU ‐F; CHANG, WEN‐CHANG ‐C; LI, CHOH HAO.

於: International Journal of Peptide and Protein Research, 卷 17, 編號 2, 01.01.1981, p. 235-238.

研究成果: 雜誌貢獻文章

YEUNG, HIN‐WING ‐W ; YAMASHIRO, DONALD ; TSENG, LIANG‐FU ‐F ; CHANG, WEN‐CHANG ‐C ; LI, CHOH HAO. / HUMAN β‐ENDORPHIN : SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31. 於: International Journal of Peptide and Protein Research. 1981 ; 卷 17, 編號 2. 頁 235-238.
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abstract = "Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.",
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AU - YAMASHIRO, DONALD

AU - TSENG, LIANG‐FU ‐F

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