Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells

Hsin An Chen, Chi Cheng Li, Yu Jung Lin, Tso Fu Wang, Ming Cheng Chen, Yen Hao Su, Yu Lan Yeh, V. Vijaya Padma, Po Hsiang Liao, Chih Yang Huang

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1 引文 斯高帕斯(Scopus)

摘要

Hepatocellular carcinoma is a common type of liver cancer. Resistance to chemotherapeutic agents is a major problem in cancer therapy. MicroRNAs have been reported in cancer development and tumor growth; however, the relationship between chemoresistance and hepatocellular carcinoma needs to be fully investigated. Here, we treated hepatocellular carcinoma cell line (HA22T) with a histone deacetylase inhibitor to establish hepatocellular carcinoma-resistant cells (HDACi-R) and investigated the molecular mechanisms of chemoresistance in HCC cells. Although histone deacetylase inhibitor could not enhance cell death in HDACi-R but upregulation of miR-107 decreased cell viability both in parental cells and resistance cells, decreased the expression of cofilin-1, enhanced ROS-induced cell apoptosis, and dose-dependently sensitized HDACi-R to HDACi. Further, miR-107 upregulation resulted in tumor cell disorganization in both HA22T and HDACi-R in a mice xenograft model. Our findings demonstrated that miR-107 downregulation leads to hepatocellular carcinoma cell resistance in HDACi via a cofilin-1-dependent molecular mechanism and ROS accumulation.
原文英語
頁(從 - 到)12046-12057
頁數12
期刊Aging
13
發行號8
DOIs
出版狀態已發佈 - 2021

ASJC Scopus subject areas

  • 老化
  • 細胞生物學

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