Hormone therapy for prostate cancer and the risk of stroke: A 5-year follow-up study

Shiu Dong Chung, Yi Kuang Chen, Fang Jen Wu, Herng Ching Lin

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Objective To examine the 5-year risk of stroke among patients with prostate cancer (PC) receiving androgen deprivation therapy (ADT) in Taiwan, using a population-based dataset. Patients and Methods This prospective case-control study used data sourced from the Longitudinal Health Insurance Database. The study included 365 patients with PC; 64 (17.6%) received ADT for more than 1 month. Cox proportional hazards regression was used to evaluate the association between ADT and the risk of stroke during the subsequent 5-year follow-up period, after adjusting for sociodemographic characteristics and hypertension, diabetes, coronary heart disease, heart failure, atrial fibrillation and hyperlipidaemia. Results In the total sample of 365 patients with PC, 68 (18.6%) patients had strokes during the 5-year follow-up period. These included 11 patients with PC who received ADT (17.2% of all patients who received ADT) and 57 patients who did not receive ADT (18.9% of patients who did not receive ADT). After adjusting for potential confounders, no significant difference in the hazard of stroke was found between patients with PC who did and did not receive ADT (hazard ratio, 1.09; 95% confidence interval, 0.80-1.50). Conclusions There was no significant difference in the risk of stroke between ethnic Chinese patients with PC who did and did not receive ADT, after adjusting for potential confounders.
原文英語
頁(從 - 到)1001-1005
頁數5
期刊BJU International
109
發行號7
DOIs
出版狀態已發佈 - 四月 2012

指紋

Prostatic Neoplasms
Androgens
Stroke
Hormones
Therapeutics
Health Insurance
Hyperlipidemias
Taiwan
Atrial Fibrillation
Coronary Disease
Case-Control Studies
Heart Failure
Databases
Confidence Intervals
Hypertension

ASJC Scopus subject areas

  • Urology

引用此文

Hormone therapy for prostate cancer and the risk of stroke : A 5-year follow-up study. / Chung, Shiu Dong; Chen, Yi Kuang; Wu, Fang Jen; Lin, Herng Ching.

於: BJU International, 卷 109, 編號 7, 04.2012, p. 1001-1005.

研究成果: 雜誌貢獻文章

Chung, Shiu Dong ; Chen, Yi Kuang ; Wu, Fang Jen ; Lin, Herng Ching. / Hormone therapy for prostate cancer and the risk of stroke : A 5-year follow-up study. 於: BJU International. 2012 ; 卷 109, 編號 7. 頁 1001-1005.
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abstract = "Objective To examine the 5-year risk of stroke among patients with prostate cancer (PC) receiving androgen deprivation therapy (ADT) in Taiwan, using a population-based dataset. Patients and Methods This prospective case-control study used data sourced from the Longitudinal Health Insurance Database. The study included 365 patients with PC; 64 (17.6{\%}) received ADT for more than 1 month. Cox proportional hazards regression was used to evaluate the association between ADT and the risk of stroke during the subsequent 5-year follow-up period, after adjusting for sociodemographic characteristics and hypertension, diabetes, coronary heart disease, heart failure, atrial fibrillation and hyperlipidaemia. Results In the total sample of 365 patients with PC, 68 (18.6{\%}) patients had strokes during the 5-year follow-up period. These included 11 patients with PC who received ADT (17.2{\%} of all patients who received ADT) and 57 patients who did not receive ADT (18.9{\%} of patients who did not receive ADT). After adjusting for potential confounders, no significant difference in the hazard of stroke was found between patients with PC who did and did not receive ADT (hazard ratio, 1.09; 95{\%} confidence interval, 0.80-1.50). Conclusions There was no significant difference in the risk of stroke between ethnic Chinese patients with PC who did and did not receive ADT, after adjusting for potential confounders.",
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