Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women

Jehn Hsiahn Yang, Chin Der Chen, Ming Yih Wu, Kuang Han Chao, Yu Shih Yang, Hong Nerng Ho

研究成果: 雜誌貢獻文章

38 引文 (Scopus)

摘要

Objective: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). Design: Prospective study. Setting: University teaching hospital.Patient(s): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). Intervention(s): Continuous usage of E2 valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group. Main Outcome Measure(s): Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the 51Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT. Result(s): NK cytotoxicity, interferon-γ production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3+CD25+ and CD3+HLA-DR+ were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group. Conclusion(s): Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT. Copyright (C) 2000 American Society for Reproductive Medicine.
原文英語
頁(從 - 到)261-267
頁數7
期刊Fertility and Sterility
74
發行號2
DOIs
出版狀態已發佈 - 八月 1 2000
對外發佈Yes

指紋

CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Postmenopause
Interleukin-5
Hormone Replacement Therapy
Menopause
Natural Killer Cells
Interferon-gamma
Interleukin-2
Prospective Studies
T-Lymphocytes
Control Groups
Valerates
Immunophenotyping
Medroxyprogesterone Acetate
K562 Cells
HLA-DR Antigens
Mitogens
Teaching Hospitals
Flow Cytometry

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

引用此文

Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. / Yang, Jehn Hsiahn; Chen, Chin Der; Wu, Ming Yih; Chao, Kuang Han; Yang, Yu Shih; Ho, Hong Nerng.

於: Fertility and Sterility, 卷 74, 編號 2, 01.08.2000, p. 261-267.

研究成果: 雜誌貢獻文章

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abstract = "Objective: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). Design: Prospective study. Setting: University teaching hospital.Patient(s): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). Intervention(s): Continuous usage of E2 valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group. Main Outcome Measure(s): Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the 51Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT. Result(s): NK cytotoxicity, interferon-γ production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3+CD25+ and CD3+HLA-DR+ were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group. Conclusion(s): Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT. Copyright (C) 2000 American Society for Reproductive Medicine.",
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AU - Wu, Ming Yih

AU - Chao, Kuang Han

AU - Yang, Yu Shih

AU - Ho, Hong Nerng

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N2 - Objective: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). Design: Prospective study. Setting: University teaching hospital.Patient(s): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). Intervention(s): Continuous usage of E2 valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group. Main Outcome Measure(s): Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the 51Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT. Result(s): NK cytotoxicity, interferon-γ production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3+CD25+ and CD3+HLA-DR+ were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group. Conclusion(s): Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT. Copyright (C) 2000 American Society for Reproductive Medicine.

AB - Objective: To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT). Design: Prospective study. Setting: University teaching hospital.Patient(s): Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group). Intervention(s): Continuous usage of E2 valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group. Main Outcome Measure(s): Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the 51Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT. Result(s): NK cytotoxicity, interferon-γ production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3+CD25+ and CD3+HLA-DR+ were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group. Conclusion(s): Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT. Copyright (C) 2000 American Society for Reproductive Medicine.

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