Homozygous ALDH2∗2 is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men

Yueh Feng Sung, Chun Chung Lu, Jiunn Tay Lee, Yi Jen Hung, Chaur Jong Hu, Jiann Shing Jeng, Hung Yi Chiou, Giia Sheun Peng

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Background and Purpose - The ∗2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was associated with hypertension and ischemic stroke. This study intended to further investigate whether the above variant of ALDH2 increases the risk for ischemic stroke in Taiwanese. Methods - A case-control study was conducted on 914 patients with acute ischemic stroke and 746 nonstroke controls. Polymerase chain reaction and sequencing were used to identify the ALDH2 genotype. Vascular risk factors, stroke subtypes, vascular stenosis, and stroke outcomes were analyzed. Results - ALDH2 genotypes differed significantly between male controls (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=53.8% versus 39.9% versus 6.4%) and male patients with ischemic stroke (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=51.5% versus 37.3% versus 11.2%; P=0.048). No significant difference was found between groups for female patients (P=0.228). Multivariate logistic regression analysis revealed that the ALDH2∗2/∗2 genotype was an independent risk factor for ischemic stroke in male patients (odds ratio, 1.93 [95% confidence interval, 1.07-3.46]; P=0.028). Further analysis of men with ischemic stroke demonstrated that the polymorphism of ALDH2 was not related to vascular risk factors, severity of vascular atherosclerosis, stroke subtypes, and stroke functional outcomes. Conclusions - The study demonstrated that ALDH2∗2/∗2 may be an independent risk factor for ischemic stroke in Taiwanese men, but not in Taiwanese women.
原文英語
頁(從 - 到)2174-2179
頁數6
期刊Stroke
47
發行號9
DOIs
出版狀態已發佈 - 九月 1 2016

指紋

Stroke
Aldehyde Dehydrogenase
Genes
Genotype
Blood Vessels
Genome-Wide Association Study
Case-Control Studies
Coronary Artery Disease
Atherosclerosis
Pathologic Constriction
Logistic Models
Alleles
Odds Ratio
Regression Analysis
Confidence Intervals
Hypertension
Polymerase Chain Reaction
Enzymes
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

引用此文

Sung, Y. F., Lu, C. C., Lee, J. T., Hung, Y. J., Hu, C. J., Jeng, J. S., ... Peng, G. S. (2016). Homozygous ALDH2∗2 is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. Stroke, 47(9), 2174-2179. https://doi.org/10.1161/STROKEAHA.116.013204

Homozygous ALDH2∗2 is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. / Sung, Yueh Feng; Lu, Chun Chung; Lee, Jiunn Tay; Hung, Yi Jen; Hu, Chaur Jong; Jeng, Jiann Shing; Chiou, Hung Yi; Peng, Giia Sheun.

於: Stroke, 卷 47, 編號 9, 01.09.2016, p. 2174-2179.

研究成果: 雜誌貢獻文章

Sung, Yueh Feng ; Lu, Chun Chung ; Lee, Jiunn Tay ; Hung, Yi Jen ; Hu, Chaur Jong ; Jeng, Jiann Shing ; Chiou, Hung Yi ; Peng, Giia Sheun. / Homozygous ALDH2∗2 is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. 於: Stroke. 2016 ; 卷 47, 編號 9. 頁 2174-2179.
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title = "Homozygous ALDH2∗2 is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men",
abstract = "Background and Purpose - The ∗2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was associated with hypertension and ischemic stroke. This study intended to further investigate whether the above variant of ALDH2 increases the risk for ischemic stroke in Taiwanese. Methods - A case-control study was conducted on 914 patients with acute ischemic stroke and 746 nonstroke controls. Polymerase chain reaction and sequencing were used to identify the ALDH2 genotype. Vascular risk factors, stroke subtypes, vascular stenosis, and stroke outcomes were analyzed. Results - ALDH2 genotypes differed significantly between male controls (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=53.8{\%} versus 39.9{\%} versus 6.4{\%}) and male patients with ischemic stroke (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=51.5{\%} versus 37.3{\%} versus 11.2{\%}; P=0.048). No significant difference was found between groups for female patients (P=0.228). Multivariate logistic regression analysis revealed that the ALDH2∗2/∗2 genotype was an independent risk factor for ischemic stroke in male patients (odds ratio, 1.93 [95{\%} confidence interval, 1.07-3.46]; P=0.028). Further analysis of men with ischemic stroke demonstrated that the polymorphism of ALDH2 was not related to vascular risk factors, severity of vascular atherosclerosis, stroke subtypes, and stroke functional outcomes. Conclusions - The study demonstrated that ALDH2∗2/∗2 may be an independent risk factor for ischemic stroke in Taiwanese men, but not in Taiwanese women.",
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AU - Hu, Chaur Jong

AU - Jeng, Jiann Shing

AU - Chiou, Hung Yi

AU - Peng, Giia Sheun

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N2 - Background and Purpose - The ∗2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was associated with hypertension and ischemic stroke. This study intended to further investigate whether the above variant of ALDH2 increases the risk for ischemic stroke in Taiwanese. Methods - A case-control study was conducted on 914 patients with acute ischemic stroke and 746 nonstroke controls. Polymerase chain reaction and sequencing were used to identify the ALDH2 genotype. Vascular risk factors, stroke subtypes, vascular stenosis, and stroke outcomes were analyzed. Results - ALDH2 genotypes differed significantly between male controls (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=53.8% versus 39.9% versus 6.4%) and male patients with ischemic stroke (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=51.5% versus 37.3% versus 11.2%; P=0.048). No significant difference was found between groups for female patients (P=0.228). Multivariate logistic regression analysis revealed that the ALDH2∗2/∗2 genotype was an independent risk factor for ischemic stroke in male patients (odds ratio, 1.93 [95% confidence interval, 1.07-3.46]; P=0.028). Further analysis of men with ischemic stroke demonstrated that the polymorphism of ALDH2 was not related to vascular risk factors, severity of vascular atherosclerosis, stroke subtypes, and stroke functional outcomes. Conclusions - The study demonstrated that ALDH2∗2/∗2 may be an independent risk factor for ischemic stroke in Taiwanese men, but not in Taiwanese women.

AB - Background and Purpose - The ∗2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was associated with hypertension and ischemic stroke. This study intended to further investigate whether the above variant of ALDH2 increases the risk for ischemic stroke in Taiwanese. Methods - A case-control study was conducted on 914 patients with acute ischemic stroke and 746 nonstroke controls. Polymerase chain reaction and sequencing were used to identify the ALDH2 genotype. Vascular risk factors, stroke subtypes, vascular stenosis, and stroke outcomes were analyzed. Results - ALDH2 genotypes differed significantly between male controls (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=53.8% versus 39.9% versus 6.4%) and male patients with ischemic stroke (∗1/∗1 versus ∗1/∗2 versus ∗2/∗2=51.5% versus 37.3% versus 11.2%; P=0.048). No significant difference was found between groups for female patients (P=0.228). Multivariate logistic regression analysis revealed that the ALDH2∗2/∗2 genotype was an independent risk factor for ischemic stroke in male patients (odds ratio, 1.93 [95% confidence interval, 1.07-3.46]; P=0.028). Further analysis of men with ischemic stroke demonstrated that the polymorphism of ALDH2 was not related to vascular risk factors, severity of vascular atherosclerosis, stroke subtypes, and stroke functional outcomes. Conclusions - The study demonstrated that ALDH2∗2/∗2 may be an independent risk factor for ischemic stroke in Taiwanese men, but not in Taiwanese women.

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