HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer

Bi Fei Huang, Huey En Tzeng, Po Chun Chen, Chao Qun Wang, Chen Ming Su, Yan Wang, Gui Nv Hu, Yong Ming Zhao, Qian Wang, Chih Hsin Tang

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 4 SNPs of the HMGB1 gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls. Patients with one G allele in the rs1360485 or rs2249825 domains are likely to progress to T2 tumor and lymph node metastasis. In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors. Furthermore, having one C allele in the rs1412125 domain increased the risk of pathologic grade 3 disease in HER2-enriched and TNBC tumors. Our results indicate that genetic variations in the HMGB1 gene may serve as an important predictor of breast cancer progression and metastasis.
原文英語
頁(從 - 到)580-586
頁數7
期刊International Journal of Medical Sciences
15
發行號6
DOIs
出版狀態已發佈 - 三月 12 2018

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer」主題。共同形成了獨特的指紋。

  • 引用此

    Huang, B. F., Tzeng, H. E., Chen, P. C., Wang, C. Q., Su, C. M., Wang, Y., Hu, G. N., Zhao, Y. M., Wang, Q., & Tang, C. H. (2018). HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer. International Journal of Medical Sciences, 15(6), 580-586. https://doi.org/10.7150/ijms.23462