HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan

Yung Feng Yen, I. An Jen, Marcelo Chen, Yu Ching Lan, Chun Yuan Lee, Pei Hung Chuang, Yun Lee, Yi Ming Arthur Chen

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

Background: HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. Objectives: The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. Methods: Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event. Results: Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36). Conclusions: The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.
原文英語
頁(從 - 到)493-499
頁數7
期刊Journal of Acquired Immune Deficiency Syndromes
75
發行號5
DOIs
出版狀態已發佈 - 八月 15 2017
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Medicine(all)

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