Histone demethylases in prostate cancer

Ling Yu Wang, Wenchang Guo, Kevin Kim, Mamata Pochampalli, Chiu Lien Hung, Yoshihiro Izumiya, Hsing Jien Kung

研究成果: 書貢獻/報告類型章節

摘要

Accumulating evidence has suggested that epigenetic alternations are as important as genetic mutations in cancer development. It is proposed that tumors are arisen by "malignant reprogramming" driven by a combination of both genetic and epigenetic changes. It therefore comes as no surprise that histone demethylases, the newest members of the histone modifying enzymes, are found to be targets of mutations and dysregulation in cancer cells. In this review article, we provide an overview of the types of histone demethylases whose genetic structure or expression is altered in cancers, the action of histone demethylases in cancer development and their potential inhibitors. Special emphasis is placed on the roles of histone demethylases in prostate cancer progression.

原文英語
主出版物標題Nuclear Signaling Pathways and Targeting Transcription in Cancer
發行者Humana Press Inc.
頁面373-397
頁數25
ISBN(列印)9781461480389
DOIs
出版狀態已發佈 - 2014
對外發佈

出版系列

名字Cancer Drug Discovery and Development
88
ISSN(列印)2196-9906
ISSN(電子)2196-9914

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科
  • 藥物發現

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