Histogranin reduced brain injury after transient focal ischemia in rats

Y. H. Chiang, G. J. Chen, H. Shen, J. Chou, Y. Wang

研究成果: 雜誌貢獻文章同行評審


Excitatory amino acids (EAAs) play an important role during ischemic brain injury. In this study we examined the protective effect of histogranin (HN), an endogenous peptide that antagonizes excitatory amino acids-mediated activity noncompetitively, in an animal model of cerebral ischemia. Adult rats were anesthetized with chloral hydrate. Histogranin was given intracerebroventricularly before a 60-min middle cerebral artery occlusion (MCAo). Animals were examined for their locomotor activity 2 days after MCAo. Histogranin significantly increased locomotor activity in the stroke rats. Histogranin pretreatment reduced the volume of cerebral infarction and the caspase-3 immunoreactivity in the stroke animals. Taken together, our data suggest that histogranin is protective against ischemic brain injury. The protective effect may involve anti-apoptotic mechanisms.

頁(從 - 到)211-215
期刊Neuroscience Letters
出版狀態已發佈 - 十月 9 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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