Higher serum potassium level associated with late stage chronic kidney disease

Ming Fang Hsieh, I. Wen Wu, Chin Chan Lee, Shun Yin Wang, Mai-Szu Wu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Background: The serum potassium (K +) level is kept in a narrow range to sustain normal physiology within the human body by the kidneys. The serum K + level in different stages of chronic kidney disease (CKD) remains undefined. Methods: We conducted a cross-sectional study to observe the serum K + level in patients without clinical manifestations of hyperkalemia in the late stages of CKD (stages 3-5). A total of 531 patients with late stage CKD were included and followed up for at least 1 year, from March 2006 to May 2007. The patients were sub-grouped by stages of CKD, which were determined by a "Modification of Diet in Renal Disease" equation estimating the glomerular filtration rate (eGFR). The serum creatinine, eGFR and K + levels were recorded at least twice during the study. We analyzed the average K + level in these late-stage CKD patients. Results: The average K + level increased along with renal function deterioration in the late stages of CKD (stage 3: 4.36 ± 0.49; stage 4: 4.50 ± 0.55; stage 5: 4.69 ± 0.73 mEq/L, p < 0.05). Men and patients with diabetes mellitus, a low eGFR, and a low hemoglobin might have higher levels of serum K +. We also noticed that there was a linear increase in the standard deviation of the serum K + level as renal function deteriorated. The use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers was not associated with hyperkalemia in our patients. Conclusion: Our results reflected that the serum K + level increased in correlation with the decline in the eGFR in the late stages of CKD. Also, male gender, diabetes mellitus, and anemia might be risk factors for higher K + levels in CKD patients. The variation in the serum K + level became wider as renal failure progressed.
原文英語
頁(從 - 到)418-425
頁數8
期刊Chang Gung Medical Journal
34
發行號4
出版狀態已發佈 - 2011
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

指紋

深入研究「Higher serum potassium level associated with late stage chronic kidney disease」主題。共同形成了獨特的指紋。

引用此