Higher order arrangement of the eukaryotic nuclear bodies

I. Fan Wang, Narsa M. Reddy, C. K.James Shen

研究成果: 雜誌貢獻文章同行評審

162 引文 斯高帕斯(Scopus)

摘要

The nuclei of eukaryotic cells consist of discrete substructures. These substructures include the nuclear bodies, which have been implicated in a number of biological processes such as transcription and splicing. However, for most nuclear bodies, the details of involvement in these processes in relation to their three-dimensional distributions in the nucleus are still unclear. Through the analysis of TDP, a protein functional in both transcriptional repression and alternative splicing, we have identified a new category of nuclear bodies within which the TDP molecules reside. Remarkably, the TDP bodies (TBs) colocalize or overlap with several different types of nuclear bodies previously suggested to function in transcription or splicing. Of these nuclear bodies, the Gemini of coiled bodies (GEM) seems to associate with TB through the interaction between survival motor neuron (SMN) protein and TDP. Furthermore, TB sometimes appears to be the bridge of two or more of these other nuclear bodies. Our data suggest the existence of a hierarchy and possibly functional arrangement of the nuclear bodies within the eukaryotic nuclei.

原文英語
頁(從 - 到)13583-13588
頁數6
期刊Proceedings of the National Academy of Sciences of the United States of America
99
發行號21
DOIs
出版狀態已發佈 - 十月 15 2002
對外發佈

ASJC Scopus subject areas

  • 多學科

指紋

深入研究「Higher order arrangement of the eukaryotic nuclear bodies」主題。共同形成了獨特的指紋。

引用此