High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease

Yung Chuan Chen, Ching Tsuen Shen, Nan Koong Wang, Yi Ling Huang, Hsin Hui Chiu, Chun An Chen, Shuenn Nan Chiu, Ming Tai Lin, Jou Kou Wang, Mei Hwan Wu

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of age). Methods: We enrolled 104 subjects into our study, who were separated into the following 3 groups and controls: 1): 22 KD patients with angiography-confirmed CAL which persisted for an average of 12.5 years after onset of KD; 2) 38 KD patients with regressed aneurysms; 3) 44 KD patients without any coronary complications from the disease onset; and 4) 31 age-matched (18.7 ± 1.88 years old) healthy controls. Plasma levels of high-sensitivity C reactive protein (hs-CRP) were measured for all participants. Results: Plasma levels of hs-CRP were significantly higher in KD patients than in the controls, regardless of their coronary severity. However, there was no significant difference in hs-CRP levels among KD patients with different severities of CAL. Of the candidate risk factors of elevated hs-CRP such as body mass index, gender, coronary severity, and levels of high-density lipoprotein-cholesterol, linear regression analysis showed the only independent predictor of hs-CRP levels was BMI (β = 0.306, p = 0.01), rather than patient grouping (p = 0.091). Conclusions: Our study found that levels of hs-CRP are significantly higher in adolescent and young adult patients with a history of KD, comparedwith age-matched controls. Lowgrade inflammation may play a minor rolewhen KD patients enter into adulthood. body mass index (BMI), rather than coronary severity, was independently associated with the elevation of hs-CRP levels, one of biomarkers for further cardiovascular event. Therefore, ongoing control and management of BMI may be one of beneficial strategies that can be employed to help avoid elevation of hs-CRP levels in KD patients.

原文英語
頁(從 - 到)473-477
頁數5
期刊Acta Cardiologica Sinica
31
發行號6
DOIs
出版狀態已發佈 - 十一月 1 2015
對外發佈Yes

指紋

Mucocutaneous Lymph Node Syndrome
C-Reactive Protein
Young Adult
Body Mass Index
Coronary Vessels
Inflammation
HDL Cholesterol
Aneurysm
Coronary Disease
Linear Models
Angiography
Biomarkers
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Chen, Y. C., Shen, C. T., Wang, N. K., Huang, Y. L., Chiu, H. H., Chen, C. A., ... Wu, M. H. (2015). High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease. Acta Cardiologica Sinica, 31(6), 473-477. https://doi.org/10.6515/ACS20150424E

High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease. / Chen, Yung Chuan; Shen, Ching Tsuen; Wang, Nan Koong; Huang, Yi Ling; Chiu, Hsin Hui; Chen, Chun An; Chiu, Shuenn Nan; Lin, Ming Tai; Wang, Jou Kou; Wu, Mei Hwan.

於: Acta Cardiologica Sinica, 卷 31, 編號 6, 01.11.2015, p. 473-477.

研究成果: 雜誌貢獻文章

Chen, YC, Shen, CT, Wang, NK, Huang, YL, Chiu, HH, Chen, CA, Chiu, SN, Lin, MT, Wang, JK & Wu, MH 2015, 'High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease', Acta Cardiologica Sinica, 卷 31, 編號 6, 頁 473-477. https://doi.org/10.6515/ACS20150424E
Chen, Yung Chuan ; Shen, Ching Tsuen ; Wang, Nan Koong ; Huang, Yi Ling ; Chiu, Hsin Hui ; Chen, Chun An ; Chiu, Shuenn Nan ; Lin, Ming Tai ; Wang, Jou Kou ; Wu, Mei Hwan. / High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease. 於: Acta Cardiologica Sinica. 2015 ; 卷 31, 編號 6. 頁 473-477.
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title = "High sensitivity C Reactive Protein (hsCRP) in adolescent and young adult patients with history of kawasaki disease",
abstract = "Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of age). Methods: We enrolled 104 subjects into our study, who were separated into the following 3 groups and controls: 1): 22 KD patients with angiography-confirmed CAL which persisted for an average of 12.5 years after onset of KD; 2) 38 KD patients with regressed aneurysms; 3) 44 KD patients without any coronary complications from the disease onset; and 4) 31 age-matched (18.7 ± 1.88 years old) healthy controls. Plasma levels of high-sensitivity C reactive protein (hs-CRP) were measured for all participants. Results: Plasma levels of hs-CRP were significantly higher in KD patients than in the controls, regardless of their coronary severity. However, there was no significant difference in hs-CRP levels among KD patients with different severities of CAL. Of the candidate risk factors of elevated hs-CRP such as body mass index, gender, coronary severity, and levels of high-density lipoprotein-cholesterol, linear regression analysis showed the only independent predictor of hs-CRP levels was BMI (β = 0.306, p = 0.01), rather than patient grouping (p = 0.091). Conclusions: Our study found that levels of hs-CRP are significantly higher in adolescent and young adult patients with a history of KD, comparedwith age-matched controls. Lowgrade inflammation may play a minor rolewhen KD patients enter into adulthood. body mass index (BMI), rather than coronary severity, was independently associated with the elevation of hs-CRP levels, one of biomarkers for further cardiovascular event. Therefore, ongoing control and management of BMI may be one of beneficial strategies that can be employed to help avoid elevation of hs-CRP levels in KD patients.",
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AU - Chen, Yung Chuan

AU - Shen, Ching Tsuen

AU - Wang, Nan Koong

AU - Huang, Yi Ling

AU - Chiu, Hsin Hui

AU - Chen, Chun An

AU - Chiu, Shuenn Nan

AU - Lin, Ming Tai

AU - Wang, Jou Kou

AU - Wu, Mei Hwan

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N2 - Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of age). Methods: We enrolled 104 subjects into our study, who were separated into the following 3 groups and controls: 1): 22 KD patients with angiography-confirmed CAL which persisted for an average of 12.5 years after onset of KD; 2) 38 KD patients with regressed aneurysms; 3) 44 KD patients without any coronary complications from the disease onset; and 4) 31 age-matched (18.7 ± 1.88 years old) healthy controls. Plasma levels of high-sensitivity C reactive protein (hs-CRP) were measured for all participants. Results: Plasma levels of hs-CRP were significantly higher in KD patients than in the controls, regardless of their coronary severity. However, there was no significant difference in hs-CRP levels among KD patients with different severities of CAL. Of the candidate risk factors of elevated hs-CRP such as body mass index, gender, coronary severity, and levels of high-density lipoprotein-cholesterol, linear regression analysis showed the only independent predictor of hs-CRP levels was BMI (β = 0.306, p = 0.01), rather than patient grouping (p = 0.091). Conclusions: Our study found that levels of hs-CRP are significantly higher in adolescent and young adult patients with a history of KD, comparedwith age-matched controls. Lowgrade inflammation may play a minor rolewhen KD patients enter into adulthood. body mass index (BMI), rather than coronary severity, was independently associated with the elevation of hs-CRP levels, one of biomarkers for further cardiovascular event. Therefore, ongoing control and management of BMI may be one of beneficial strategies that can be employed to help avoid elevation of hs-CRP levels in KD patients.

AB - Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of age). Methods: We enrolled 104 subjects into our study, who were separated into the following 3 groups and controls: 1): 22 KD patients with angiography-confirmed CAL which persisted for an average of 12.5 years after onset of KD; 2) 38 KD patients with regressed aneurysms; 3) 44 KD patients without any coronary complications from the disease onset; and 4) 31 age-matched (18.7 ± 1.88 years old) healthy controls. Plasma levels of high-sensitivity C reactive protein (hs-CRP) were measured for all participants. Results: Plasma levels of hs-CRP were significantly higher in KD patients than in the controls, regardless of their coronary severity. However, there was no significant difference in hs-CRP levels among KD patients with different severities of CAL. Of the candidate risk factors of elevated hs-CRP such as body mass index, gender, coronary severity, and levels of high-density lipoprotein-cholesterol, linear regression analysis showed the only independent predictor of hs-CRP levels was BMI (β = 0.306, p = 0.01), rather than patient grouping (p = 0.091). Conclusions: Our study found that levels of hs-CRP are significantly higher in adolescent and young adult patients with a history of KD, comparedwith age-matched controls. Lowgrade inflammation may play a minor rolewhen KD patients enter into adulthood. body mass index (BMI), rather than coronary severity, was independently associated with the elevation of hs-CRP levels, one of biomarkers for further cardiovascular event. Therefore, ongoing control and management of BMI may be one of beneficial strategies that can be employed to help avoid elevation of hs-CRP levels in KD patients.

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