High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

Sun Ma, Lih Ing Shieh, Chao Ching Huang

研究成果: 雜誌貢獻文章

8 引文 (Scopus)

摘要

High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

原文英語
頁(從 - 到)37-51
頁數15
期刊Applied Biochemistry and Biotechnology
53
發行號1
DOIs
出版狀態已發佈 - 四月 1995
對外發佈Yes

指紋

Metabolites
Protons
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Urine
Newborn Infant
Succinic Acid
Citric Acid
Meconium Aspiration Syndrome
Nuclear magnetic resonance spectroscopy
Newborn Respiratory Distress Syndrome
Lactic Acid
Sudden Infant Death
Citric Acid Cycle
Asphyxia
Oxygen
Serum

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Microbiology and Biotechnology
  • Environmental Engineering
  • Molecular Biology

引用此文

High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants. / Ma, Sun; Shieh, Lih Ing; Huang, Chao Ching.

於: Applied Biochemistry and Biotechnology, 卷 53, 編號 1, 04.1995, p. 37-51.

研究成果: 雜誌貢獻文章

@article{b9e6d733c0534d53a6c29e81dcb8a560,
title = "High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants",
abstract = "High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.",
keywords = "H-NMR spectroscopy, Asphyxia, fetal distress, meconium aspiration syndrome, urine",
author = "Sun Ma and Shieh, {Lih Ing} and Huang, {Chao Ching}",
year = "1995",
month = "4",
doi = "10.1007/BF02783480",
language = "English",
volume = "53",
pages = "37--51",
journal = "Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology",
issn = "0273-2289",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

AU - Ma, Sun

AU - Shieh, Lih Ing

AU - Huang, Chao Ching

PY - 1995/4

Y1 - 1995/4

N2 - High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

AB - High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

KW - H-NMR spectroscopy

KW - Asphyxia

KW - fetal distress

KW - meconium aspiration syndrome

KW - urine

UR - http://www.scopus.com/inward/record.url?scp=0029283997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029283997&partnerID=8YFLogxK

U2 - 10.1007/BF02783480

DO - 10.1007/BF02783480

M3 - Article

C2 - 7625824

AN - SCOPUS:0029283997

VL - 53

SP - 37

EP - 51

JO - Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology

JF - Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology

SN - 0273-2289

IS - 1

ER -