High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

Cheng Huang Shen, Hsiao Yen Hsieh, Yuan Hung Wang, Syue Yi Chen, Chun Liang Tung, Jiann Der Wu, Chang TeLin Lin, Michael W Y Chan, Cheng Da Hsu, Deching Chang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.

原文英語
頁(從 - 到)893-898
頁數6
期刊Experimental and Therapeutic Medicine
1
發行號5
DOIs
出版狀態已發佈 - 九月 2010

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

指紋 深入研究「High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma」主題。共同形成了獨特的指紋。

引用此