High-density lipoprotein prevents organ damage in endotoxemia

Ru Ping Lee, Nien Tsung Lin, Yann Fen Chiou Chao, Chia-Chin Lin, Horng Jyh Harn, Hsing I. Chen

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.
原文英語
頁(從 - 到)250-260
頁數11
期刊Research in Nursing and Health
30
發行號3
DOIs
出版狀態已發佈 - 6月 2007

ASJC Scopus subject areas

  • 護理(全部)

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