High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Etienne Simon-Loriere, Ren-Jye Lin, Sita Mint Kalayanarooj, Ampaiwan Chuansumrit, Isabelle Casademont, Shyr Yi Lin, Han Pang Yu, Worachart Lert-Itthiporn, Wathanee Chaiyaratana, Nattaya Tangthawornchaikul, Kanchana Tangnararatchakit, Sirijitt Vasanawathana, Bi Lan Chang, Prapat Suriyaphol, Sutee Yoksan, Prida Malasit, Philipe Despres, Richard Paul, Yi Ling Lin, Anavaj Sakuntabhai

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P
原文英語
頁(從 - 到)2011-2020
頁數10
期刊Journal of Infectious Diseases
212
發行號12
DOIs
出版狀態已發佈 - 2015

指紋

Dengue Virus
Dengue
Genes
Virus Diseases
Antiviral Agents
Culicidae
Innate Immunity
Interferons
Shock
Cohort Studies
Cell Culture Techniques
Odds Ratio
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

引用此文

Simon-Loriere, E., Lin, R-J., Kalayanarooj, S. M., Chuansumrit, A., Casademont, I., Lin, S. Y., ... Sakuntabhai, A. (2015). High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue. Journal of Infectious Diseases, 212(12), 2011-2020. https://doi.org/10.1093/infdis/jiv321

High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue. / Simon-Loriere, Etienne; Lin, Ren-Jye; Kalayanarooj, Sita Mint; Chuansumrit, Ampaiwan; Casademont, Isabelle; Lin, Shyr Yi; Yu, Han Pang; Lert-Itthiporn, Worachart; Chaiyaratana, Wathanee; Tangthawornchaikul, Nattaya; Tangnararatchakit, Kanchana; Vasanawathana, Sirijitt; Chang, Bi Lan; Suriyaphol, Prapat; Yoksan, Sutee; Malasit, Prida; Despres, Philipe; Paul, Richard; Lin, Yi Ling; Sakuntabhai, Anavaj.

於: Journal of Infectious Diseases, 卷 212, 編號 12, 2015, p. 2011-2020.

研究成果: 雜誌貢獻文章

Simon-Loriere, E, Lin, R-J, Kalayanarooj, SM, Chuansumrit, A, Casademont, I, Lin, SY, Yu, HP, Lert-Itthiporn, W, Chaiyaratana, W, Tangthawornchaikul, N, Tangnararatchakit, K, Vasanawathana, S, Chang, BL, Suriyaphol, P, Yoksan, S, Malasit, P, Despres, P, Paul, R, Lin, YL & Sakuntabhai, A 2015, 'High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue', Journal of Infectious Diseases, 卷 212, 編號 12, 頁 2011-2020. https://doi.org/10.1093/infdis/jiv321
Simon-Loriere, Etienne ; Lin, Ren-Jye ; Kalayanarooj, Sita Mint ; Chuansumrit, Ampaiwan ; Casademont, Isabelle ; Lin, Shyr Yi ; Yu, Han Pang ; Lert-Itthiporn, Worachart ; Chaiyaratana, Wathanee ; Tangthawornchaikul, Nattaya ; Tangnararatchakit, Kanchana ; Vasanawathana, Sirijitt ; Chang, Bi Lan ; Suriyaphol, Prapat ; Yoksan, Sutee ; Malasit, Prida ; Despres, Philipe ; Paul, Richard ; Lin, Yi Ling ; Sakuntabhai, Anavaj. / High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue. 於: Journal of Infectious Diseases. 2015 ; 卷 212, 編號 12. 頁 2011-2020.
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AU - Lin, Shyr Yi

AU - Yu, Han Pang

AU - Lert-Itthiporn, Worachart

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AU - Tangnararatchakit, Kanchana

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AU - Chang, Bi Lan

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AU - Yoksan, Sutee

AU - Malasit, Prida

AU - Despres, Philipe

AU - Paul, Richard

AU - Lin, Yi Ling

AU - Sakuntabhai, Anavaj

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KW - Dengue virus

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