Heterogeneous expression of potassium currents and pacemaker currents potentially regulates arrhythmogenesis of pulmonary vein cardiomyocytes

Yao Chang Chen, Nan Hung Pan, Chen Chuan Cheng, Satoshi Higa, Yi Jen Chen, Shih Ann Chen

研究成果: 雜誌貢獻文章

40 引文 斯高帕斯(Scopus)

摘要

Potassium Currents on Pulmonary Veins' Arrhythmogenesis. Introduction: The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. Methods: Whole-cell patch clamp was used to investigate the action potentials, transient outward currents (I to), sustained outward potassium currents (IKsus), rapid delayed rectifier potassium currents (IKr), inward rectifier potassium current (IK1), pacemaker currents (If), and transient inward currents in isolated rabbit PV single fast (≥2.5 Hz) and slow (to and IK1, and larger If but with similar IKsus, IKr, and transient inward currents. However, only few fast (2/34) and slow (1/23) PV pacemaker cardiomyocytes contained barium-sensitive hyperpolarization-activated time-dependent current (I KH). Conclusions and Implications: The fast and slow PV pacemaker had different electrophysiological characteristics. Ito, IK1, and If may regulate the beating rates of PV pacemaker cardiomyocytes. (J Cardiovasc Electrophysiol, Vol. 20, pp. 1039-1045)

原文英語
頁(從 - 到)1039-1045
頁數7
期刊Journal of Cardiovascular Electrophysiology
20
發行號9
DOIs
出版狀態已發佈 - 九月 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

指紋 深入研究「Heterogeneous expression of potassium currents and pacemaker currents potentially regulates arrhythmogenesis of pulmonary vein cardiomyocytes」主題。共同形成了獨特的指紋。

  • 引用此