Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng, Chiung Fang Chang, Wen Juei Jeng, I. Shyan Sheen, Chi Juei Jeng

研究成果: 雜誌貢獻回顧型文獻同行評審

59 引文 斯高帕斯(Scopus)

摘要

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

原文英語
頁(從 - 到)337-347
頁數11
期刊Critical Reviews in Oncology/Hematology
94
發行號3
DOIs
出版狀態已發佈 - 6月 1 2015
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科

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