Heterogeneity in radiosensitivity of human diploid fibroblasts from keloids and normal skins

Shiuh Ma, Rong Hwang Fang, Wushou P. Chang

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Colony-forming ability was employed in evaluating the susceptibility to in vitro gamma ionizing radiation in human diploid skin fibroblasts (HDF). Twelve pairs of HDF, each composed of fibroblasts from excised keloid lesion and local normal skin tissue as its control, were studied in patients with clinically persistent keloids. Parameters of radiosensitivity, both D0 and D10, and growth kinetics were examined. The radiosensitivity in three of the 12 keloids (25%) were demonstrated significantly increased than their counterpart controls, even though no difference in growth kinetics in between. Moreover, a broad range in the radiosensitivity of fibroblast cells was demonstrated and it is suggested that there is a great heterogeneity of cellular response to radiation in HDF.

原文英語
頁(從 - 到)289-292
頁數4
期刊Cell Biology International
20
發行號4
DOIs
出版狀態已發佈 - 4月 1996
對外發佈

ASJC Scopus subject areas

  • 細胞生物學

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