Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai Peng Sim, Angela Liu, Daniel S. Pilch, Leroy-Fong Liu, Edmond J. Lavoie

研究成果: 雜誌貢獻文章同行評審

45 引文 斯高帕斯(Scopus)

摘要

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

原文英語
頁(從 - 到)719-723
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
10
發行號8
DOIs
出版狀態已發佈 - 4月 2000
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 有機化學
  • 藥物發現
  • 藥學科學

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