Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai Peng Sim, Angela Liu, Daniel S. Pilch, Leroy-Fong Liu, Edmond J. Lavoie

研究成果: 雜誌貢獻文章同行評審

45 引文 斯高帕斯(Scopus)

摘要

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

原文英語
頁(從 - 到)719-723
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
10
發行號8
DOIs
出版狀態已發佈 - 四月 2000
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

指紋 深入研究「Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors」主題。共同形成了獨特的指紋。

引用此